I was just testing a Meteor app with different operating systems and browsers, and it’s completely unusable on IE Edge / Windows 10.
The laptop isn’t brand new, but it does have a dual core Intel CPU with 6Gb of memory. On Chrome and Firefox the app is snappy as usual, but with IE, just opening a form can take 2-3 seconds. Subscriptions load approximately 5x slower than on Chrome.
The app I’m testing is just “classic” Meteor with ViewModel sugaring on top of Blaze.